A Direct Deposition Method for Coupling Matrix-assisted Laser Desorption/Ionization Mass Spectrometry with Gel Permeation Chromatography for Polymer Characterization

1997 ◽  
Vol 11 (10) ◽  
pp. 1134-1138 ◽  
Author(s):  
Camille E. Kassis ◽  
Joseph M. DeSimone ◽  
Richard W. Linton ◽  
Edward E. Remsen ◽  
Gary W. Lange ◽  
...  
Keyword(s):  
Gel Permeation Chromatography ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Coupling Matrix ◽  
Polymer Characterization ◽  
Desorption Ionization ◽  
Gel Permeation ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

A Modified Thermal Deposition Unit for Gel-Permeation Chromatography with Matrix-Assisted Laser Desorption/Ionization and Electrospray Ionization Time-of-Flight Analysis

2002 ◽  
Vol 8 (5) ◽  
pp. 397-401 ◽  
Author(s):  
E. Peter Maziarz ◽  
X. Michael Liu
Keyword(s):  
Time Of Flight ◽  
Gel Permeation Chromatography ◽  
Laser Desorption ◽  
Laser Desorption Ionization ◽  
Thermal Deposition ◽  
Desorption Ionization ◽  
Gel Permeation ◽  
Continuous Deposition ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

We describe a modified commercially available thermal deposition unit that incorporates a post-column mixing cell for gel-permeation chromatography (GPC) effluent and matrix solution prior to continuous deposition onto a matrix-assisted laser desorption/ionization (MALDI) sample target. This modification overcomes the shortcomings of using a prefabricated matrix foil. This GPC MALDI method with time-of-flight (ToF) mass spectrometry is demonstrated by the analysis of a poly(dimethylsiloxane) (PDMS) sample used in the production of implantable device materials.

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